作者：姜兰香段正芳张民夫苏忠兰王延龙
单位：130041长春，白求恩医科大学第二临床学院皮肤科
关键词：孢子丝菌病；碘化钾；预防；实验动物
中华皮肤科杂志980510【摘要】目的研究低治疗量碘化钾对孢子丝菌病发病的影响，为预防本病提供理论依据。方法采用含碘化钾的饮水饲养实验鼠，并设对照组，2周后行腹腔接种孢子丝菌，于接种后的第3～8周，每周分批处死实验鼠，剖检，观察发病情况、病理学改变及真菌学所见。结果实验鼠本病的发病率显著下降（P<0.01），其下降与碘化钾的用量有关。结论低治疗量碘化钾具有预防孢子丝菌病发病的作用。
PotassiumIodideinthePreventionofSporotrichosisinExperimentalAnimalJiangLanxiang,DuanZhengfang,ZhangMinfu,etal.DepartmentofDermatology,SecondClinicalCollege,NormanBethuneUniversityofMedicalSciences,Changchun130041
【Abstract】ObjectiveToinvestigatetheeffectofpotassiumiodideontheincidenceofsporotrichosis,andprovidethetheoreticalbasisforthepreventionofsporotrichosis.MethodsExperimentalmiceweredividedinto4groups,group1～3werefedwithwatercontainingdifferentdosesofpotassiumiodide,andnopotassiumiodidewasgiventothecontrolgroup.Aftertwoweeks,thefungiwereinoculatedintraperitoneallytoallthemice.Inthethirdtotheeighthweeks,themiceweresacrificedeveryweekinbatches.Theinfection,pathologicalchangesandmycologicalfindingsofthemicewereobserved.ResultsTheincidencerateofexperimentalsporotrichosiswassignificantlydecreasedinthemice（P<0.01）,andthedecreasewasrelatedtothedosageofpotassimuiodide.ConclusionTheresultsshowthatpotassiumiodidemaybeofuseinthepreventionofsporotrichosis.......
