儿童精神分裂症患者脑脊液中氨基酸神经递质的测定基本信息作者:专业：班级:研究方向：学校:指导老师:写作日期:字数:2,317编号:50类别:医学〉临床医学级别:学术论文郭沈昌柯小燕谭钊安李振国王键罗硕军金利波【摘要】目的探讨儿童精神分裂症可能的发病机制。方法采用反向高效液相色谱法测定16例儿童精神分裂症患儿（患儿组）和11例患阑尾炎的患儿（对照组）脑脊髓液（CSF）中谷氨酸、天门冬氨酸（兴奋性氨基酸）和甘氨酸（抑制性氨基酸）的浓度并进行比较。结果患儿组CSF中谷氨酸为[（9.7±3.1）μmol]，甘氨酸为[（9.7±3.7）μmol]，低于对照组[分别为（41.9±22.3）μmol和（16.1±11.8）μmol]，而天门冬氨酸含量两组差异无显著性。结论儿童精神分裂症的发病机制中可能有氨基酸神经递质的参与。【关键词】精神分裂症儿童脑脊髓液氨基酸类DeterminationofAmino-acidNeurotrasmitteinCerebrospinalFluid（CSF）ofChildhoodSchizophrenicsGUOShenchang,KeXiaoyan,TanZhaoanetal.TheMentalHealthCenterShantouUniversityGuangdong515063【Abstract】Objective:Tostudythepathologicmecharismofchildhoodschizophrenics.Methods:Thehigh-performanceliquidchromatography（HPLC）ofreversewasusedtodeteminatedandcomparedtheconcentrationsofglutamic-acid,aspartic-acid（excitatoryamino-acid）andglycine（inhibitoryamino-acid）inCSFof16patientswithchildhoodschizohprenicsand11controlsofchildhoodappendicitis.Results:Theconcentrationsofglutamic-acid[（9.7士3.1）μmol]andglycine[（9.7士3.7）μmol]inCSFofthepatientswithchildhoodschizophreniawereobviouslylowerthanthose[（41.9士22.3）μmoland（16.1士11.8）μmol,respectively）ofcontrols;buttherewasnosignificantlydifferenceofthecontentofaspartic-acidbetweentwogroups.Conclusions:Itisprobablethattheamino-acidsneurotrasmitterwasparticipatedinthepathologicmechanismofchildhoodschizophrenics..【KeyWords】SchizophreniaChildhoodCerebrospinalfluidAmino-acids
