前言动物肥厚性心肌病的临床所见、心脏超声波图、肉眼组织病理、冠状小动脉变化、胶原纤维组织变化等,与人类肥厚性心肌病非常相似;遗传学分析,人类及猫肥厚性心肌病均为家族性常染色体显性遗传类型。动物肥厚性心肌病可为理想模型来研究人类疾病,而且动物肥厚性心肌病小冠状动脉病变与人类冠状动脉粥样化血管切除或皮下血管内腔扩张术后小冠状动脉再阻塞相同,可为人类疾病之模型。尤其猪心脏血行、生理及形态均与人类心脏相似,故猪肥厚性心肌病实为人类肥厚性心肌病研究之理想动物模型。
Aspontaneouslyoccurringdiseaseofdomesticcats,dogs,andpigswasidentifiedbyechocardiographyandwasstrikinglysimilarinitsphenotypicexpressiontohypertrophiccardiomyopathy(HCM)inhumans.Itwascharacterizedbyunexplainedleftventricularhypertrophyinvarietyofpatternswithorwithoutevidenceofoutlowobstruction.AffectedcatsdidnothavephenotypicevidenceofHCMbefore6monthsofage,developedHCMduringadolescenceanddevelopedsevereHCMduringyoungadulthoodasinhumans.Papi...