前言[目的]探讨混配农药染毒对家兔大脑、肝及肾组织脂质过氧化的影响及意义。[方法]将家兔随机分为不同剂量的6个混配农药染毒组,1个单剂农药(丙溴磷)染毒组和1个对照组。混配农药组均经皮肤给予不同剂量和种类混配农药染毒,于染毒15d后测定各组大脑、肝及肾组织中谷胱甘肽过氧化物酶(GSHPx)活力与丙二醛(MDA)的浓度,以及染毒前后血清胆碱脂酶(ChE)活力。[结果]除高剂量混配农药染毒组外,其余各组染毒后ChE活性均在正常范围内,但各混配农药染毒组家兔GSHPx活力和MDA浓度大脑分别为(648~801)U/ml、(288~452)nmol/L,肝分别为(546~691)U/ml、(342~537)nmol/L,肾分别为(427~571)U/ml、(227~471)nmol/L,均较对照组和丙溴磷组增高或显著增高(P<005,P<001)。[结论]混配农药可导致家兔大脑、肝及肾组织脂质过氧化增强,这对混配农药中毒所致组织功能受损的早期评价和防治可能有一定意义
Thepurposewastostudytheeffectsoflowdosemixedpesticideonlipidperoxidationinthebrain,liverandkidneyinrabbits.Rabbitswererandomlydividedinto6mixedpesticidepoisoninggroups,onesinglepesticidegroupandacontrolgroup.Theactivitiesofglutathioneperoxidase(GSHPx)andtheconcentrationofmalondialdehyde(MDA)inbrain,liverandkidneyweremeasuredinrabbitstreatedwiththepesticidesfor15days.ChEwasnormalineachgroupexceptforthehighdosegroup.Afterpo...