姜敏,汤浩,刘峥艳,张义侠,傅宝玉,中国医科大学附属第一医院消化内科辽宁省沈阳市110001
项目负责人:姜敏,110001,辽宁省沈沈阳市和平区南京北街155号,中国医科大学附属第一医院.jiang-min@163.com
电话:024-23256666-6199
收稿日期:2004-12-08接受日期:2004-12-28
摘要
目的:探讨肠易激综合征（irritablebowelsyndrome，IBS）患者内脏感知异常与临床腹部症状的相关性.
方法:用问卷调查的方式对符合RomeII诊断标准的腹泻、便秘、腹泻与便秘交替三种亚型的IBS患者与内脏感知异常有关的腹部症状进行调查分析;部分患者接受了直肠水囊容积初始阈值和紧迫感阈值的测定.
结果:腹痛是IBS患者内脏感知异常的主要临床表现;与正常对照组比较，IBS患者直肠容积的初始阈值和紧迫感阈值明显降低（腹泻型IBS组初始感觉阈值33±2.02vs56±4.04mL，紧迫感阈值86±4.53vs135±3.55mL，P<0.01;便秘型和腹泻便秘交替型IBS组初始感觉阈值分别为42±3.69vs56±4.04，38±3.56vs56±4.04mL，紧迫感阈值分别为96±3.45vs135±3.55mL，102±4.78vs135±3.55mL，P<0.05），以腹痛为主和以非腹痛为主的IBS患者相比，以腹痛为主的IBS患者的初始阈值和紧迫感阈值明显降低（初始感觉阈值26±2.29vs42±3.34ml，P<0.05，紧迫感阈值68±4.20vs94±4.37mL，P<0.01）.
结论:腹痛是内脏感知异常最主要的临床表现，内脏神经敏感性增加即内脏感知异常是IBS的主要发病机制.
姜敏,汤浩,刘峥艳,张义侠,傅宝玉.肠易激综合征内脏感知异常与临床症状的相关性.世界华人消化杂志2005;13（4）:561-564
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编辑张海宁（姜敏,汤浩,刘峥艳,张义侠,傅宝玉）
