前言患者女,23岁。左锁骨、腰部右侧及左膝部出现肿块并溃疡4个月,组织病理检查示组织中大量浆细胞及异物巨细胞;PAS染色显示大量散在或成团的孢子,经鉴定证实为新生隐球菌。连续T淋巴细胞亚群分析显示CD4+T淋巴细胞明显减少,占总T淋巴细胞数20%以下。无人类免疫缺陷病毒（HIV）感染。诊断为特发性CD4+T淋巴细胞减少症伴播散性皮肤隐球菌病。主要给予两性霉素B治疗,1个月后溃疡愈合。
A23-year-oldwomanpresentedlumpsandulcersonherleftclavicle;rightloinandleftkneeareasfor4months.Largenumbersofplasmacellsandforeign-bodygiantcellswereshowninhistopathologicexamination;andPASstainingdemonstratedtherewerescatteredandclumpedspores;whichwereidentifiedasCryptococcusneoformans.Tlymphocytesubgroupanalysisshowedlymphocytopenia;withreductionofCD4+lymphocytes;andCD4+countwaslessthan20%ofthetotalTcellcount.Noevidenceofhumanimm...
