前言目的 探讨涎腺癌mdr1mRNA的表达及其耐药机制。方法 采用PCR法对35例涎腺癌进行mdr1mRNA检测。结果 涎腺癌中mdr1mRNA表达率为31。4%,IOD值为0。295。结论 mdr1mRNA在涎腺癌的阳性表达可能与肿瘤的耐药性有关
ObjectiveTostudytheexpressionofmdr1mRNAandthemechanismofdrugresistanceofsalivaryglandcarcinoma.Methods35casesofsalivaryglandcarcinomawereinvestigatedformdr1mRNAusingRT-PCR.ResultsIn35casesofcarcinoma,mdr1RNAwasdetectedpositivein11samples（31.4%）,thevalueofIODwas0.295.ConclusionTheexpressionofmdr1isfoundinsalivaryglandcarcinoma,anditisprobablyrelatedtodrugresistance.
