前言目的:探讨选择性IgA缺乏症（SelectiveIgADeficiency,SIgAD）病人的发病规律及免疫学、临床表现。方法:以单向免疫扩散法及酶联免疫吸附试验测定血清IgG、IgA、IgM、IgE,以间接免疫荧光法检测抗核抗体,以PHA淋巴细胞转化试验形态学检查法测定细胞免疫功能。结果:28例患者血清IgA低于01gL,且IgG、IgA、IgM、IgE基本正常;4091%的SIgAD患者血清抗核抗体阳性;6667%的患者淋巴细胞转化率低于正常;临床表现主要以自身免疫性疾病最为多见,呼吸道感染、消化系统疾病次之。结论:SIgAD患者常伴有其他免疫学检查的异常,临床上易合并自身免疫病。
Objective:InviewoftheimmunologicalandclinicalmanifestationofSIgAD.Methods:SingleradialimmunodiffusiontechniquewasemploiedtodetermineserumIgG?IgA?IgMandtheenzymelinkedimmunosorbentassay（ELISA）hadbeenusedtomeasureserumIgE;antiunclearantibodies（ANA）weretestwithindirectimmunofluorescencetechnique,cellularimmunitywastestwithlymphocytetranslationassay.Results:TweentyeightpatientswithselectiveIgAdeficiencywereseenduringthelasttweenyears（IgA<1g/L）,all...
